Placenta is a highly specialised multifaceted organ that supports the life of growing fetus throughout the pregnancy and also serves as a source of nutrient, gaseous and waste products exchange between the mother and the fetal circulation. During the course of gestation, the placenta undergoes multiple changes which are crucial for establishing a healthy pregnancy. Placenta majorly consists of trophoblast cells which are also the building unit of placenta and mediate functions like apposition, invasion and embedment of blastocyst into the maternal endometrium. Trophoblast cells are of two major types i.e., Cytotrophoblast cells and syncytiotrophoblast cells respectively, former are involved in invasion, column formation and vascular remodelling process while latter are involved in forming placental barrier via which all the exchanges take place and also expressing markers which help in avoiding semi-allogenic fetus rejection. Defect in the processes mediated by trophoblast cells directly affects the placentation process and thence can cause multiple pregnancy complications such as pre-eclampsia, fetal growth restriction, preterm birth and stillbirth. Thus, any physiological and environmental influences in mother’s body can be communicated to the fetus via placenta. Also, these factors can affect the biology of trophoblast cells. We are living in an era of polluted air and it is considered worldwide most serious health risk according to World Health Organisation (WHO). A report by WHO suggests that 13 of the world’s most polluted cities are in India and in terms of PM2.5 high level in air, India ranks fifth. Air pollution is a global matter of concern and poses serious risks to pregnant women and their unborn baby. My research is aimed to identify and analyse the effect of toxic pollutants such as Sulphur dioxide and Particulate matter on the trophoblast cells and thus pregnancy. A part of my research work also warrants to identify the transgenerational effect of these pollutants on the fetal health and growth which would be achieved by performing in-silico analysis and animal experiments.